Uncontrolled Moderate to Severe Eosinophilic Asthma
Sponsored by Kymera Therapeutics, Inc.
Objective
To evaluate the efficacy of multiple doses of KT-621 compared to placebo in participants with uncontrolled moderate to severe eosinophilic asthma.
Key Eligibility Criteria
Below are the main inclusion and exclusion criteria for this study. The full eligibility assessment will be discussed with you by our research team during screening.
Key Inclusion Criteria
- Adults aged ≥18 years
- Physician-diagnosed asthma for ≥12 months
- Moderate-to-severe asthma inadequately controlled despite standard therapy
- Stable asthma background therapy prior to screening
- Demonstrated airflow limitation on spirometry
- Willing and able to comply with study procedures
- Documented history of at least 1 asthma exacerbation requiring either treatment with systemic corticosteroids and/or a hospitalization or emergency/urgent medical care visit for acute asthma worsening within the past 52 weeks prior to the Screening visit (V1)
Key Exclusion Criteria
- Diagnosis of COPD or other significant chronic lung disease
- Current smokers or significant smoking history (per protocol limits)
- Recent asthma exacerbation requiring systemic corticosteroids
- Use of biologic therapies within protocol-defined washout period
- Clinically significant uncontrolled comorbidities
- Active or chronic infections (e.g., TB, hepatitis, HIV)
- Pregnant or breastfeeding
- Known hypersensitivity to study drug or excipients
Apply for this study
Fill out the form below to see if you qualify. Our research coordinators will contact you directly to discuss your eligibility — there's no obligation to participate.
Your information is kept confidential and only used for study eligibility purposes.
Advancing research, one participant at a time.
Clinical trials depend on volunteers like you. By participating, you gain access to potential new treatments while helping researchers discover safer, more effective therapies for everyone.
- Access to investigational treatments and expert medical care
- Close monitoring by our experienced research team
- Contribute to better treatments for future patients
- Confidential — your information is protected at every step