Moderate to Severe Asthma — Pfizer
Sponsored by Pfizer Inc.
Objective
The purpose of the study is to evaluate the efficacy and safety of PF-07275315 in participants with inadequately controlled moderate-to-severe asthma, and to provide a preliminary assessment of dose-response.
Key Eligibility Criteria
Below are the main inclusion and exclusion criteria for this study. The full eligibility assessment will be discussed with you by our research team during screening.
Key Inclusion Criteria
- Adults ≥18 years
- Documented diagnosis of moderate-to-severe asthma
- Inadequately controlled asthma despite medium-to-high dose inhaled corticosteroids plus controller
- Baseline eosinophil count eligibility (≥300 cells/µL for primary analysis population)
- Demonstrated reversible airway obstruction
- Stable asthma therapy prior to screening
- Able to complete spirometry and PRO assessments
- History of persistent, moderate-to-severe asthma for at least 12 months prior to screening and have experienced at least 1 asthma exacerbation requiring treatment with systemic steroids (oral or parenteral) for 3 days or more within 12 months of the screening visit
Key Exclusion Criteria
- Current smokers or excessive smoking history
- Diagnosis of COPD or other chronic lung disease
- Recent asthma exacerbation requiring systemic steroids
- Prior or current biologic therapy within washout period
- Clinically significant cardiovascular, renal, hepatic, or immunologic disease
- Active infection (TB, hepatitis, HIV)
- History of malignancy (with limited exceptions)
- Pregnancy or breastfeeding
- Use of prohibited concomitant medications
Apply for this study
Fill out the form below to see if you qualify. Our research coordinators will contact you directly to discuss your eligibility — there's no obligation to participate.
Your information is kept confidential and only used for study eligibility purposes.
Advancing research, one participant at a time.
Clinical trials depend on volunteers like you. By participating, you gain access to potential new treatments while helping researchers discover safer, more effective therapies for everyone.
- Access to investigational treatments and expert medical care
- Close monitoring by our experienced research team
- Contribute to better treatments for future patients
- Confidential — your information is protected at every step